心肌梗死后缝隙连接和缓慢传导和室性心动
SaffitzJE,KlépJunctions,SlowConduction,andVentricularTachycardiaAfterMyocardial[J].JournaloftheAmericanCollegeofCardiology,,60(12):-.
Abstract：
EDITORIALCOMMENT
eyhaveallconvergedontheideathatgapjunctionremodelingcanreduceintercellularcouplingandtherebyslowconductioninwaysthatcontributeimportantlytothepathogenesisofre-entrantVTaftermyocardialinfarction.
cognitionofthisconcepthasalsoraisedtheobviouspossibilitythatpreservationorenhancementofintercellularcouplinginthe
infarctborderzonemightdecreasetheriskforre-entrantVT.
ncludethatincreasedexpressionofCx43inhealedinfarctborderzonesissuf?cienttoreducearrhythmiasusceptibilityandtheysuggestfurtherthattargetedCx43geransfermightbeaviablefuturetherapyinpatientswithpost-infarctionVT.
ecisegeicinterventionsinalargeanimalmodelwouldbeofgreatpotentialvalue,therefore,inelucidatingtheroleofspeci?cmoleculesinVTaftermyocardialinfarction
tentialclinicalapplicationsofso-calledantiarrhythmicpeptidesorother
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